VUMC Biospecimen Storage

  • Interested in storing your collection in the Biostore system?

    Please fill out this brief REDCap survey. VANTAGE staff will follow up to learn more about your samples and provide recommendations on storage format. Estimated pricing is also available upon request. 

     

    Project Overview

    VUMC received an NIH S10 High-End Instrumentation Award (PI: Dr. James Goldenring, Surgical Sciences) to purchase an Azenta Life Sciences Biostore II automated freezer system for large-scale biobanking. The first build of its kind, VUMC's Biostore II has capacity for up to 10 million samples and features both -20C and -80C banks for optimal preservation of multiple biospecimen types. VUMC has committed more than $5.1M over five years to supplement the Biostore II purchase and develop a comprehensive automated freezer shared resource that offers biospecimen collection management and associated services. Some of these funds will subsidize user fees so that Vanderbilt investigators are able to utilize the resource at low cost. The ~300,000 sample Vanderbilt BioVU collection was migrated to the automated storage facility in June 2021 and is now operating from there full-time (see photos at right.) The -80C freezer banks were commissioned in 2022 and are now fully operational.

    The facility is now accepting user-submitted sample requests, providing the ideal solution for managing Vanderbilt researchers' new and existing biospecimen collections. Samples are dropped off and picked up via a convenient sample transfer point in the VANTAGE laboratory (Medical Center North), and transported at-temperature via courier to the automated storage facility. After submitting a sample pull request, samples can picked up in the VANTAGE laboratory. 

     

    Why use the automated biospecimen storage facility?

    • Multiple layers of power and cooling redundancy for superior sample integrity

    • Institutionally-subsidized pricing for Vanderbilt investigators makes storage cost-effective

    • User-facing LIMS software aids investigators with sample annotation and tracking

    • Depth of expertise from staff with years of biobanking experience (e.g. BioVU collection)

    • Enhanced sample security via controlled access and 24/7 monitoring

    • Separate zones for -20C and -80C sample storage

    • Flexibility in container types to accommodate a broad range of collections

    • Rapid sample loading and picking minimizes temperature fluctuations

    • Improved space, energy and labor efficiency vs. non-automated in-lab freezers

    • Expanded capacity for large and growing biospecimen collections, e.g. multiyear studies

     

    Operations Advisory Committee

    An Operations Advisory Committee for the new automated freezer shared resource is comprised of VUMC faculty and staff experienced in biobanking and shared resource management. The committee provides development support and strategic oversight for the shared resource’s biospecimen management plan.

  • VUMC maintains several freezer farm rooms in Medical Center North and Light Hall.  This space is available for allocation to members of VUMC research entities after an appropriate review process completed by the Freezer Resource Allocation Committee. To initiate your request for freezer farm space, please submit this short form: https://redcap.link/freezer-request

     

    The conduct of extramurally funded peer-reviewed research deemed impactful in accordance with VUMC Strategic Directions and other institutional metrics is given the highest priority for allocation of freezer farm space. The following prioritization scale guides the allocation of freezer farm space in order of institutional priority and alignment with VUMC Strategic Directions:

     

    1. Commitments made in executive letters of offer to institutional leaders or individual investigators consistent with actual need per the conditions stipulated in the offer and current capacity.
    2. Research funded by the National Institute of Health (NIH) or other federal organizations providing full indirect costs that requires the acquisition, curation, and use of human biospecimens.
    3. Impactful research not funded by extramural support with immediate or near-term potential for commercialization, licensing, or similarly valuated intellectual property involving acquisition, curation, and use of human biospecimens.
    4. Research funded by the NIH or other federal organizations providing full indirect costs that involves nonhuman samples of impactful, long-term value.
    5. Impactful research not funded by extramural support with immediate or near-term potential for commercialization, licensing, or similarly valuated intellectual property involving rare or other highly valuable samples of long-term utility.
    6. Disease/health-relevant research that is: a) conducted with non-federally funded agencies providing fully expected indirect costs, such as clinical trials or contractual industry-sponsored projects, involving curation of human biospecimens; or b) conducted with non-federally funded agencies providing fully expected indirect costs, such as clinical trials or contractual industry-sponsored projects, involving rare or other samples of impactful, long-term value.