Recent Publications

2017

2016

Lealani Mae (Leah) Acosta, MD, MPH

Lealani Mae (Leah)
Acosta
M.D., M.P.H.
Associate Professor
Neurology

Dr. Lealani Mae (Leah) Acosta is an Associate Professor of Neurology and a board-certified neurologist specializing in neurodegenerative memory disorders. Currently she serves as co-editor of the Humanities section of the journal Neurology. Dr. Acosta joined the Vanderbilt University School of Medicine faculty in 2013. She completed graduate studies, obtaining a master's in public health at Vanderbilt, with her research focused on error frequency and quality in a task of semantic fluency in patients with mild cognitive impairment. 

She attended The George Washington University, graduating summa cum laude in psychology. She completed graduate studies in psychology, philosophy, and physiology at Oxford University in Oxford, UK. On returning to the United States, she finished both her medical education and residency training in Neurology at the University of Virginia in Charlottesville, VA. She completed fellowship in Cognitive and Behavioral Neurology at the University of Florida in Gainesville, FL, under the mentorship of Dr. Kenneth Heilman, focusing on creativity. Her interest in this topic stems in part from her own hobbies of poetry, drawing, and calligraphy. Her range of publications reflects these varied interests, including peer-reviewed research articles and creative writing, primarily poetry.

Dr. Acosta is the principal investigator for Alector Frontotemporal Dementia clinical trial in patients with the progranulin gene mutation and other Alzheimer's disease clinical trial research. As a study physician for Vanderbilt Memory & Alzheimer’s Center, Dr. Acosta performed clinical evaluations, lumbar punctures for cerebrospinal fluid acquisition, and reviewed laboratory findings. She also is a sub-investigator or study physician for other research projects in Alzheimer's disease and other clinical trials at Vanderbilt, such as the Alzheimer's Disease Neuroimaging Initiative, the MIND (Memory Improvement through Nicotine Dosing) Study, and the Bringing to Light the Risk Factors and Incidence of Neuropsychological Dysfunction in ICU Survivors (BRAIN-2). As a Clinician Educator working with medical students, she has served as a Master Clinical Teacher, working one-on-one supervising histories and physicals, and a Portfolio Coach, and currently serves as College Mentor within the Vanderbilt University School of Medicine. She has published research on medical education. Dr. Acosta has been instrumental in protocol implementation for evaluation of normal pressure hydrocephalus, which won the prestigious Vanderbilt University Medical Center Elevate Team Credo Award in 2023, and the lumbar puncture clinic for the neurology residents.

Bassel W. Abou-Khalil, MD

Bassel
W.
Abou-Khalil
MD
Clinical Director
VUMC Epilepsy Monitoring Unit (EMU)
Professor
Neurology
Program Director
Clinical Neurophysiology Fellowship

Dr. Abou-Khalil is Professor of Neurology and Director of the Epilepsy Center at Vanderbilt University Medical Center. He is board certified in Neurology, Clinical Neurophysiology, and Epilepsy. He is founder and Director of the Vanderbilt Epilepsy Monitoring Unit and Clinical Epilepsy Program and was the founding director of the Vanderbilt Clinical Neurophysiology Training Program, which was accredited by ACGME in 1996. Dr. Abou-Khalil is a member of the American Neurological Association, a fellow of the American Academy of Neurology (Epilepsy Section), a fellow of the American Epilepsy Society, and a fellow of the American Clinical Neurophysiology Society.

Dr. Abou-Khalil earned both his B.S. and his medical degree (1978) at the American University of Beirut in Beirut, Lebanon. He completed an internship and one year of residency in Internal Medicine at the American University Medical Center in Beirut. He completed his neurology residency and EEG and epilepsy fellowship at the University of Michigan Medical Center in 1985 and then was a post-doctoral fellow in Clinical Neurophysiology at the Montreal Neurologic Institute in Montreal, Quebec in 1986.

Dr. Abou-Khalil’s research interests are predominantly in the area of clinical epilepsy, including seizure semiology, anti-seizure medications, epilepsy surgery, development of new therapies for epilepsy, and clinical epilepsy genetics.

With respect to epilepsy surgery, he is interested in the analysis of seizure signs and their localizing and lateralizing significance and the localization of language and memory functions in the brain before surgery. 

He has conducted numerous trials of experimental and new antiepileptic drugs in various forms of epilepsy. Drugs currently being investigated include XEN1101 and CVL-865 for refractory focal-onset seizures, and OPC-214870 in patients with epileptic photosensitivity.