Microbiota-derived lantibiotic restores resistance against vancomycin-resistant Enterococcus. Kim S, et al. in Nature, August 21, 2019 Primary prostate cancer educates bone stroma through exosomal pyruvate kinase M2 to promote bone metastasis. Dai J, et al.

Young Kim, M.D., Ph.D., Professor of Otolaryngology and co-leader of the Translational Research and Interventional Oncology Research Program, is a clinician-scientist focused on the development of immunotherapeutic modalities for solid tumors... Click on Dr. Kim's photo to continue reading.

Long-Distance Cooperative and Antagonistic RNA Polymerase Dynamics via DNA Supercoiling. Sangjin Kim, et al. in Cell Press, September 19, 2019 TGFβ blocks IFNα/β release and tumor rejection in spontaneous mammary tumors. Guerin M, et al.

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory. Blelloch R, Poggio M, et al. in Cell Reports, April 4, 2019 Viral complementation of immunodeficiency confers protection against enteric pathogens via interferon-λ. Baldridge MT, Ingle H, et al.

Immune induction strategies in metastatic triple-negative breast cancer to enhance the sensitivity to PD-1 blockade: the TONIC trial. Voorwerk L, et al in Nature, May 13, 2019 Human Influenza A Virus Hemagglutinin Glycan Evolution Follows a Temporal Pattern to a Glycan Limit.

Plants send small RNAs in extracellular vesicles to fungal pathogen to silence virulence genes.

Dr. Heather Pua is an Assistant Professor of Pathology, Microbiology, and Immunology. She earned her B.S. in Biology and her M.D. Ph.D. in Immunology from Duke University, where she identified a role for autophagy in naive T cell survival. She then moved to the West Coast, completing residency in Anatomic Pathology, clinical fellowship in Molecular Genetic Pathology, and post-doctoral fellowship at the University of California, San Francisco. The Pua Lab studies how miRNAs regulate effector cell programs, with particular attention to their role in pathologic lung inflammation. They also investigate extracellular small RNAs, which are abundant in body fluid and were until recently dark matter in the body. These goals are accomplished using RNA biology’s molecular tool kit in combination with classic cellular immunology in both mice and humans... Click Dr. Pua's photo to continue reading.

The composition of the human microbiome, a complex ecosystem of microorganisms, plays a crucial role in lifelong health. Little is known, however, about the detailed molecular mechanisms linking health status to the microbiome of the gut, for example...