Seth graduated from the University of Pennsylvania in 2013 with a B.A. in Biochemistry and History and a M.S. in Chemistry. Following graduation, Seth joined the lab of Dr. Scott Hensley at the University of Pennsylvania and studied human antibody responses to influenza A viruses and the viral evasion of pre-existing immunity. Seth defended his PhD in 2018. In the lab, Seth is continuing to study antibody responses against respiratory viruses with special interests in defining conserved sites on viral proteins that are targeted by human antibodies and identifying how prior exposure shapes human antibody responses against viruses like influenza and SARS-CoV-2....Click the image on the left to continue reading.

Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement. McCallum M, et al. in Science, January 25, 2022 TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures. Chaurio R, et al.

Dr. Dawn Newcomb and graduate student Nowrin Chowdhury challenged each other to a game of Uno while we asked them some questions about their research.... Click the image to the left to watch!

T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma. Lozano A, et al. in Nature Medicine, January 13, 2022 Bacterial gasdermins reveal an ancient mechanism of cell death. Johnson A, et al.

Dr. Ferguson completed a BA in Human Genetics at Trinity College Dublin, and a PhD in Nutrigenomics at University College Dublin, Ireland, before moving to Philadelphia for postdoctoral training in Cardiovascular Genomics at the University of Pennsylvania. She moved to Nashville to join the faculty at Vanderbilt in October 2014... Click Dr. Ferguson's photo to continue reading.

Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis. Hinrichsen F, et al. in Cell Metabolism, December 7, 2021 Establishment and characterization of stable, diverse, fecal-derived in vitro microbial communities that model the intestinal microbiota. Aranda-Diaz A, et al.

Dr. Patrick earned her Master's degree from the University of Pennsylvania, Biochemistry and Molecular Biophysics, and her M.D./Ph.D. from the University of Texas Southwestern Medical Center. She's an Assistant Professor of Pediatrics Rheumatology at Vanderbilt where her work focuses on identifying and characterizing pathogenic molecular pathways in juvenile idiopathic arthritis and pediatric autoimmune disease.... Click Dr. Patrick's photo to continue reading.

Mapping the cellular origin and early evolution of leukemia in Down syndrome. Wagenblast E, et al. in Science, July 9, 2021 Arthritis flares mediated by tissue-resident memory T cells in the joint. Chang M, et al.

Hepatic stellate cells suppress NK cell-sustained breast cancer dormancy. Bentires-Alj M et al. in Nature, June 2, 2021 Th1 polarization defines the synovial fluid T cell compartment in oligoarticular juvenile idiopathic arthritis. Jul`e A, et al.

We sat down with Dr. Robert Carnahan from the Vanderbilt Vaccine Center to talk about antibody therapeutics and how they can be used in the fight against COVID-19... Click the image to the left to watch!